Amazing stuff!
"... Researchers ... recently carried out a study aimed at better understanding how networks of nerve cells in the spinal cord of adult mice contribute to the encoding of pain originating from exposure to heat and mechanical pain, which is caused by applied physical forces (e.g., pinches, cuts, etc.). ...
Their findings ... suggest that in mice, heat-related and mechanical pain are encoded by different neural ensembles (i.e., groups of neurons) in the spinal cord. ..."
From the abstract:
"Acute pain is an unpleasant experience caused by noxious stimuli. How the spinal neural circuits attribute differences in quality of noxious information remains unknown.
By means of genetic capturing, activity manipulation and single-cell RNA sequencing, we identified distinct neural ensembles in the adult mouse spinal cord encoding mechanical and heat pain.
Reactivation or silencing of these ensembles potentiated or stopped, respectively, paw shaking, lifting and licking within but not across the stimuli modalities.
Within ensembles, polymodal Gal+ inhibitory neurons with monosynaptic contacts to A-fiber sensory neurons gated pain transmission independent of modality.
Peripheral nerve injury led to inferred microglia-driven inflammation and an ensemble transition with decreased recruitment of Gal+ inhibitory neurons and increased excitatory drive.
Forced activation of Gal+ neurons reversed hypersensitivity associated with neuropathy.
Our results reveal the existence of a spinal representation that forms the neural basis of the discriminative and defensive qualities of acute pain, and these neurons are under the control of a shared feed-forward inhibition."
Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord (open access)
Fig. 1: Capturing ensembles encoding mechanical and heat pain in the spinal dorsal horn.
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