Good news! Cancer is history (soon)!
"... Researchers had thought of midbody remnants as the garbage bag of cell division, once considering them to be dissolved post-split, before noticing they were instead expunged.
But a new study has tracked the formation of these overlooked organelles and unpacked their internal structure, which suggests they are well-equipped to influence other cells after their primary job of cell division is done.
"... midbody is full of genetic information, RNA, that doesn't have much to do with cell division at all, but likely functions in cell communication," ...
When two body cells divide in a process called mitosis ...
The midbody assembles itself at the overlapping, outstretched ends of spindle microtubules that tether themselves to chromosomes. From there, the midbody recruits and positions the abscission machinery that cleaves the final bridge connecting the dividing cells in two. ..."
From the highlights and abstract:
"Highlights
• The midbody is the assembly site of an RNP granule which we call the MB granule
• Distinct oncogenic and pluripotent transcription factor RNAs are packaged in MBs and MBRs
• The MB and MBR are sites of active translation
• Multiple cell types including cancer, stem, and neural stem have actively translating MBRs
Summary
Long ignored as a vestigial remnant of cytokinesis, the mammalian midbody (MB) is released post-abscission inside large extracellular vesicles called MB remnants (MBRs). Recent evidence suggests that MBRs can modulate cell proliferation and cell fate decisions. Here, we demonstrate that the MB matrix is the site of ribonucleoprotein assembly and is enriched in mRNAs that encode proteins involved in cell fate, oncogenesis, and pluripotency, which we are calling the MB granule. Both MBs and post-abscission MBRs are sites of spatiotemporally regulated translation, which is initiated when nascent daughter cells re-enter G1 and continues after extracellular release. MKLP1 and ARC are necessary for the localization and translation of RNA in the MB dark zone, whereas ESCRT-III is necessary to maintain translation levels in the MB. Our work reveals a unique translation event that occurs during abscission and within a large extracellular vesicle."
Remnant of cell division could be responsible for spreading cancer (primary news source)
RNA translation marked by bright green reveals two soon-to-be-separate human cells still connected by the red microtubules that provide some structure during cell division. The dot of green in the middle is a midbody, a structure that will be released when division is complete and free to carry its significant genetic cargo away to other cells.
Graphical abstract
No comments:
Post a Comment