Cold Plasma Therapy in Chronic Wounds: Preliminary Results indicate clear superiority over standard wound treatment

Good news! This seems to be amazing stuff!

"Chronic wounds represent a significant medical and financial challenge for millions of patients as well as for healthcare systems. Wound care with standard wound therapy (SWT) is currently considered the gold standard. Recent evidence suggests that cold plasma therapy (CPT) offers promise for improving chronic wounds. With this in mind, the POWER study, funded by the German Federal Ministry of Education and Research, was conducted to investigate the efficacy of large-area plasma therapy for the treatment of chronic, non-healing wounds compared to standard wound therapy (period of four weeks). An applicator was used that generates a homogeneous plasma field over a large treatment area (for wound sizes of up to 10 x 10 cm) and achieves optimal treatment in just two minutes. The treatment is fully automatic and optimized for effect and can be carried out by non-medical personnel regardless of wound size and depth."

From the abstract:

"Chronic wounds (CWs) pose a significant health challenge in clinical practice. Standard wound therapy (SWT) is currently considered the gold standard. However, recent evidence suggests that cold plasma therapy (CPT) holds promise for improving CWs. In light of this, the POWER study was conducted as a multicenter, randomized clinical trial to investigate the effect of large-area plasma application compared with SWT in patients with chronic, non-healing arterial or venous wounds on the lower leg. To analyze the interim results, we employed a comprehensive range of statistical tests, including both parametric and non-parametric methods, as well as GLS model regression and an ordinal mixed model. Our findings clearly demonstrate that CPT therapy significantly accelerates wound closure compared with SWT. In fact, complete wound closure was exclusively observed in the CPT group during the intervention period. Additionally, the CPT group required significantly less antibiotic therapy (4%) compared with the SWT group (23%). Furthermore, CPT led to a significant reduction in wound pain and improved quality of life compared with SWT. In conclusion, the study highlights that the combination of CPT and SWT surpasses monotherapy with SWT alone."

Cold Plasma Therapy in Chronic Wounds—A Multicenter, Randomized Controlled Clinical Trial (Plasma on Chronic Wounds for Epidermal Regeneration Study): Preliminary Results - PMC

Clear superiority of CPT® cold plasma therapy over standard wound treatment POWER study (Plasma on chronic Wounds for Epidermal Regeneration) proves the clear superiority of CPT® cold plasma therapy in the treatment of chronic wounds compared to standard wound treatment!

Figure 2 presents a series of wound photographs from three patients treated with CPT (Figure 2a–g). These clinical case examples demonstrate the effectiveness of CPT for treating CW.

Significant acceleration of wound closure in the CPT group

The results of the interim analysis show that the combination of CPT and SWT is significantly superior to mono-treatment SWT in terms of efficacy alone.

One of the significant results is the significant increase of the wound closure factor to 214% when using CPT cold plasma therapy.

The acceleration of wound closure was already noticeable with the first treatment with CPT on day 2 and continued continuously until day 25.