Sunday, August 21, 2022

A three-parent technique could help transgender men have babies

They are trying very hard to make it possible! How many transgender men have ovaries? What does it cost to provide a transgender man with functioning ovaries? 

Rich Western countries have money for a lot of things and powerful minority lobbies able to change priorities in their favor.

As I have speculated here before, it is quite possible that in about 20-30 years from now we have artificial wombs so that neither women (now a.k.a. pregnant people) nor transgender men have to get pregnant and give birth anymore.

"The process involves removing pieces of a transgender man’s ovary, extracting eggs from the ovary in the lab, and swapping in parts of an egg from another person before fertilizing them with sperm to create embryos. 

Extracting eggs in the lab has helped some people have babies after surviving cancer. And the so-called three-parent technique—using parts of an egg from a third person— has been used in attempts to help people avoid passing genetic disease to their babies and to boost fertility. The new research suggests that these technologies, used in concert, could also boost a trans man’s chances of using his eggs to create a healthy embryo—and potentially have a baby—without having to undergo typical fertility treatments.  ...
The technique appears to work, and healthy babies have been born. Last year, three US-based reproductive medicine societies issued a statement concluding that the technique should no longer be considered experimental. ...
The team started with ovaries donated by 14 transgender men aged between 18 and 24, who had had the organs removed as part of their gender-affirming treatment. All the participants had been undergoing testosterone therapy for an average of 26 months, and some were also taking a drug to stop them from menstruating.
First, the team removed eggs that were days away from being released by the ovary. The team repeated the process with similarly immature eggs donated by cisgender women. After 48 hours in a lab dish, the eggs appeared to be ready to be fertilized with sperm.
In both cases, around half the immature eggs were successfully matured in the lab. But something appeared to go wrong when the team tried to fertilize the eggs with sperm. While 84% of the eggs from cisgender women could be fertilized, the figure was only around 45% for trans men. ..."

A three-parent technique could help trans men have babies | MIT Technology Review A combination of two existing techniques can help generate embryos from trans men’s eggs in the lab—without the need for distressing IVF procedures.

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