Good news! However, this early research requires further validation!
"... Piras led an international team comparing brain tissue of people who died by suicide versus those who died by natural causes. The team used the National Institutes of Health Gene Expression Omnibus to examine the orbitofrontal cortex, prefrontal cortex, and dorsolateral prefrontal cortex for genes associated with suicide.
In total, the researchers identified five genes they believe are associated with suicide based on the expression of the gene – the amount of a given gene - in the brain. The genes have connections to maladies like depression and Alzheimer’s disease. ..."
From the abstract:
"Suicide claims over 800,000 deaths worldwide, making it a serious public health problem. The etiopathophysiology of suicide remains unclear and is highly complex, and postmortem gene expression studies can offer insights into the molecular biological mechanism underlying suicide. In the current study, we conducted a meta-analysis of postmortem brain gene expression in relation to suicide. We identified five gene expression datasets for postmortem orbitofrontal, prefrontal, or dorsolateral prefrontal cortical brain regions from the Gene Expression Omnibus repository. ... We found reduced expression of the KCNJ2 (Potassium Inwardly Rectifying Channel Subfamily J Member 2), A2M (Alpha-2-Macroglobulin), AGT (Angiotensinogen), PMP2 (Peripheral Myelin Protein 2), and VEZF1 (Vascular Endothelial Zinc Finger 1) genes (FDR p<0.05). Our findings support the involvement of astrocytes, stress response, immune system, and microglia in suicide. These findings will require further validation in additional large datasets."
A review and meta-analysis of gene expression profiles in suicide (no public access)
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