About the HIV cure in the Sao Paulo Patient

I have little doubt that the cure for AIDS/HIV is practically achieved or will be achieved in the near future! If this treatment strategy was not yet ultimately successful, successor treatments will be even better!



OK, some doubts linger: " ... But he [clinical investigator running the study that includes the Sao Paulo patient] notes his team has not sampled the man’s lymph nodes or gut for the virus since he stopped treatment. ... Only two people are known to have been cured of their HIV infections: Timothy Ray Brown and a man who has asked to be referred to as the London Patient; both received bone marrow transplants [a very different treatment than the Sao Paulo patient] as part of a treatment for cancers."



Keep in mind that the study presented here had only five patients receiving the same treatment:

"To compare different reservoir-clearing strategies, Diaz and colleagues in 2015 recruited the São Paulo Patient and other individuals who had controlled their HIV infections with ARVs. The most aggressive approach, used in this man and four others, added two ARVs to the three they were already taking, in the hope this would rout out any HIV that might have dodged the standard treatment. On top of this “intensification,” the study group received nicotinamide, which can, in theory, prod infected cells to “wake up” the latent virus. When those cells make new HIV, they either self-destruct or are vulnerable to immune attack.



After 48 weeks on this intensified schedule, the five trial participants returned to their regular three-drug regimen for 3 years, after which they stopped all treatment. Four saw the virus quickly return, but the São Paulo Patient has now gone 66 weeks without signs of being infected."



An intriguing—but far from proven—HIV cure in the ‘São Paulo Patient’ | Science | AAAS A 36-year-old man in Brazil has seemingly cleared an HIV infection—making him the proof of principle in humans of a novel drug strategy designed to flush the AIDS virus out of all of its reservoirs in the body. After receiving an especially aggressive combination of antiretroviral (ARV) drugs and nicotinamide (vitamin B3), the ... Sao Paulo Patient t ... went off all HIV treatment in March 2019 and has not had the virus return to his blood.