Amazing stuff!
"... But a new study published in Cell Reports suggests the mouth may be carrying its own metabolic fingerprint. In saliva samples from 628 adults, researchers at New York University Abu Dhabi found that people living with obesity host a distinct oral microbiome, one that differs not just in species, but in what those microbes are actively doing. ...
For the study participants with obesity, bacteria were more active in pathways linked to sugar fermentation and lactate production, while showing reduced capacity to generate certain essential nutrients. Across all participants, body mass index stood out as one of the strongest drivers of oral microbial variation, suggesting the microbiome of the mouth may reflect a broader metabolic state. These changes were not random, but instead pointed in a consistent metabolic direction. Species linked to inflammation and lactate production became more prominent, including proinflammatory Streptococcus parasanguinis and Actinomyces oris, along with the lactate-producing Oribacterium sinus, while others associated with nutrient synthesis receded. A shift that went deeper than simple taxonomy. ..."
From the highlights and abstract:
"Highlights
• Oral microbiome composition and functions differ significantly in obesity
• Obesity is linked to proinflammatory and lactate-producing oral bacteria
• Obese individuals show disrupted oral metabolism and altered energy balance
• Obesity-linked metabolites correlate with cardiometabolic disease markers
Summary
Obesity is a leading global health challenge and risk factor for cardiometabolic disorders, driven in part by industrialization and low-fiber, ultra-processed diets. While the gut microbiome has been implicated in obesity, the contribution of the oral microbiome—the body’s second largest microbial ecosystem—remains underexplored. We analyze a prospective cohort of 628 Emirati adults, including multi-omics profiling of 97 obese individuals and 95 matched controls, generating the most comprehensive oral microbiome analysis to date.
Obese participants show altered microbial diversity, composition, functions, and metabolites with enrichment of proinflammatory Streptococcus parasanguinis, Actinomyces oris, and lactate-producing Oribacterium sinus. Pathways for carbohydrate metabolism, histidine degradation, and obesogenic metabolites are upregulated, whereas B-vitamin and heme biosynthesis are depleted. Corresponding metabolites—including lactate, histidine derivatives, choline, uridine, and uracil—are elevated and correlate with obesity-linked cardiometabolic markers.
These findings reveal mechanistic oral microbiome-metabolite shifts, highlighting oral microbiome-host interactions as novel targets for obesity prevention and intervention."
NYU Abu Dhabi Researchers Reveal an Association Between Mouth Bacteria and Obesity and Metabolic Health (original news release)
Integrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity (open access)
Graphical abstract
No comments:
Post a Comment