It's Y chromosome again! What an easy to pinpoint culprit! Cancer is history (soon)!
As an aside: Some feminists like to derive male inferiority to women from the Y Chromosome!
This article (Nature journal news) also contains a dubious clarification based on fashionable LGBTQ propaganda and demagoguery. Very annoying! Cringey!
"(This article uses ‘men’ to describe people with a Y chromosome, while recognizing that not all people who identify as men have a Y chromosome, and not all people who have a Y chromosome identify as men.) ... researchers have also found that the Y chromosome, which is often found in men ..."
"... Two studies, both published on 21 June in Nature, address cancers that are particularly aggressive in men: colorectal cancer and bladder cancer. One study finds that the loss of the entire Y chromosome in some cells — which occurs naturally as men age — raises the risk of aggressive bladder cancer and could allow bladder tumours to evade detection by the immune system. The other finds that a particular Y-chromosome gene in mice raises the risk of some colorectal cancers spreading to other parts of the body. ...
Lifestyle has long been given the blame for the fact that many non-reproductive cancers tend to be more frequent and more aggressive in men than women. ...
As men age, the proportion of Y-less blood cells increases, and an abundance of such cells has been linked to conditions including heart disease, neurodegenerative conditions and some cancers. ...
In mice, a therapeutic antibody that can restore the activity of those immune cells was more effective against such Y-less tumours than against tumours that still had their Y chromosome. The team found a similar trend in human tumours. ...
In a separate study, a team working on colorectal cancer in mice found that a gene on the Y chromosome called KDM5D might weaken connections between tumour cells, helping the cells to break away and spread to other parts of the body. When that gene was deleted, tumour cells became less invasive, and were more likely to be recognized by immune cells. ...
The contrast between the two findings — a protective role for the Y chromosome in bladder cancer and a harmful role for a Y-chromosome gene in colorectal cancer — emphasizes the importance of context in cancer ..."
Lifestyle has long been given the blame for the fact that many non-reproductive cancers tend to be more frequent and more aggressive in men than women. ...
As men age, the proportion of Y-less blood cells increases, and an abundance of such cells has been linked to conditions including heart disease, neurodegenerative conditions and some cancers. ...
In mice, a therapeutic antibody that can restore the activity of those immune cells was more effective against such Y-less tumours than against tumours that still had their Y chromosome. The team found a similar trend in human tumours. ...
In a separate study, a team working on colorectal cancer in mice found that a gene on the Y chromosome called KDM5D might weaken connections between tumour cells, helping the cells to break away and spread to other parts of the body. When that gene was deleted, tumour cells became less invasive, and were more likely to be recognized by immune cells. ...
The contrast between the two findings — a protective role for the Y chromosome in bladder cancer and a harmful role for a Y-chromosome gene in colorectal cancer — emphasizes the importance of context in cancer ..."
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