Recommendable! Amazing stuff! An overview article. There might even be a symbiosis going on between bacteria and fungi. Lot's of research still needs to be done.
The big caveat here is sample contamination: "Both research teams got most of their tissue and blood samples from databases, so the samples were not collected with the aim of minimizing fungal contamination ..."
"For years, evidence has been mounting that bacteria are linked to cancer, and sometimes even play a crucial part in its progression. Now, researchers have found a similar connection with another type of microorganism: fungi.
Tumours of various types of cancer contain different species of microscopic or single-celled fungus, and investigating the species that are present might one day be useful for diagnosing cancer or predicting its course ...
Like bacteria, fungal microorganisms form a crucial part of the human microbiome — a delicate balance of microbes living inside the body. ...
[researchers] catalogued fungal populations in more than 17,000 tissue and blood samples representing 35 types of cancer ...
As expected, fungi, including several types of yeast, were present in all the types of cancer included in the study, but some species were linked to different outcomes, depending on the cancer. For example, the presence of Malassezia globosa, a fungus that has previously been associated with pancreatic cancer, was linked to significantly reduced survival rates in breast cancer, the researchers found. By also characterizing the bacteria in the tumours, ... found that most types of fungus had certain bacterial species that they tended to coexist with, meaning that the tumour might favour both fungal and bacterial growth — unlike typical environments, in which fungi and bacteria compete over shared resources. ...
In another study ... looked at gastrointestinal, lung and breast tumours, and found that they tended to contain Candida, Blastomyces and Malassezia fungi, respectively. Higher levels of Candida in gastrointestinal tumour cells were linked to more gene activity that promotes inflammation, a higher rate of metastasis and lower survival rates, the researchers found. ...
Depending on the sample, there is usually only about one fungal cell for every 10,000 tumour cells ...
Furthermore, many of the fungal species in question are widespread, which makes sample contamination a serious concern ...
Both research teams got most of their tissue and blood samples from databases, so the samples were not collected with the aim of minimizing fungal contamination ..."
Like bacteria, fungal microorganisms form a crucial part of the human microbiome — a delicate balance of microbes living inside the body. ...
[researchers] catalogued fungal populations in more than 17,000 tissue and blood samples representing 35 types of cancer ...
As expected, fungi, including several types of yeast, were present in all the types of cancer included in the study, but some species were linked to different outcomes, depending on the cancer. For example, the presence of Malassezia globosa, a fungus that has previously been associated with pancreatic cancer, was linked to significantly reduced survival rates in breast cancer, the researchers found. By also characterizing the bacteria in the tumours, ... found that most types of fungus had certain bacterial species that they tended to coexist with, meaning that the tumour might favour both fungal and bacterial growth — unlike typical environments, in which fungi and bacteria compete over shared resources. ...
In another study ... looked at gastrointestinal, lung and breast tumours, and found that they tended to contain Candida, Blastomyces and Malassezia fungi, respectively. Higher levels of Candida in gastrointestinal tumour cells were linked to more gene activity that promotes inflammation, a higher rate of metastasis and lower survival rates, the researchers found. ...
Depending on the sample, there is usually only about one fungal cell for every 10,000 tumour cells ...
Furthermore, many of the fungal species in question are widespread, which makes sample contamination a serious concern ...
Both research teams got most of their tissue and blood samples from databases, so the samples were not collected with the aim of minimizing fungal contamination ..."
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