Anti-Aging Clues Lurk in Lysosomes, the Recycling Centers of the Cell

Amazing stuff! Are you ready for a longer life? How will longevity affect world human population?

"... that molecules produced during the recycling process can also serve as signals that talk to other parts of the body. 

These signals seem to play a role in determining how and when organisms grow old. ... have found evidence that the anti-aging messages are transmitted between cells too, and among different tissues ... The results suggest that lysosome signals help coordinate the body’s aging process – and prolong the lives of some organisms. ...
discovered that when lysosomes produce a fatty acid called dihomo-gamma-linoleic acid, it triggers a chain reaction of cellular messages that ultimately extend the worms’ lives. When the researchers dialed up this fatty acid signaling, worms lived 20 to 25 days, an increase from the normal lifespan of 17 days. Crucially, the signal molecule was generated in fat tissues, yet detected by neurons elsewhere in the worms. That means lysosomes produce signals that cells use to coordinate longevity across different tissues. ..."

From the abstract:

"Lysosomes are key cellular organelles that metabolize extra- and intracellular substrates. Alterations in lysosomal metabolism are implicated in aging-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to regulate aging remains unclear. Here, we report a fat-to-neuron lipid signaling pathway induced by lysosomal metabolism and its longevity promoting role in Caenorhabditis elegans. We discovered that lysosomal lipolysis in peripheral fat storage tissue up-regulates the neuropeptide signaling pathway in the nervous system to promote longevity. ... Together, these results reveal lysosomes as a signaling hub to coordinate metabolism and aging, and a lysosomal signaling mechanism that mediates intertissue communication to promote longevity."

Anti-Aging Clues Lurk in Lysosomes, the Recycling Centers of the Cell | HHMI Scientists have discovered that lysosomes in roundworms produce molecules that allow cells to ‘talk’ to one another about aging, coordinating the process across the entire organism.

Lysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity (open access, but this is the 2021 preprint version)