Amazing stuff! Are we finally coming closer to the proverbial fountain of youth! Apparently, these genes also play a critical role in cancer.
"A new study ... has revealed that the Chinmo gene is responsible for establishing the juvenile stage in insects. It also confirms that the Br-C and E93 genes play a regulatory role in insect maturity. These genes, which are also present in humans, act as a promoter and as a suppressor, respectively, of cancerous processes. ...
The results of the research, which was carried out with the fruit fly Drosophila melanogaster and the cockroach Blatella germanica, reveal that these genes have been conserved throughout the evolution of insects. Therefore, it is believed that they could play a key role in the evolution of metamorphosis. ...
Previous studies had discovered that the Br-C gene determines pupal formation in insects. In 2019, the same ... team that has led this study described the essential function of E93 to complete metamorphosis in insects and initiate the maturation of the tissues that go on to form the adult. However, the gene responsible for determining the juvenile stage was unknown until now. This study has now identified the Chimno gene as the main precursor of this stage in insects. ...
By deleting the Chinmo gene in Drosophila specimens, the scientists observed that these insects progressed to the pupal stage without completing the juvenile stage, moving to the adult stage early. ...
Chinmo and Br-C belong to the large family of BTB-ZF transcription factors—proteins involved in cancer and that are also found in humans. Although previous studies had shown that Chinmo is a precursor of cancer, the role of Br-C and E93 in this disease was unknown until now. ...
The study shows that while Chinmo is an oncogenic precursor because it promotes tissue growth and prevents differentiation, C-Br and E93 serve as tumor suppressors by activating tissue maturation. ...
The results of the study indicate that the regulatory action of Chinmo and E93 in more basal insects such as the cockroach are sufficient to determine the transition from the juvenile to the adult form. However, the introduction of the Br-C gene allowed the development of the pupae and the appearance of complete metamorphosis through a new pupal stage in insects such as flies. ..."
The results of the research, which was carried out with the fruit fly Drosophila melanogaster and the cockroach Blatella germanica, reveal that these genes have been conserved throughout the evolution of insects. Therefore, it is believed that they could play a key role in the evolution of metamorphosis. ...
Previous studies had discovered that the Br-C gene determines pupal formation in insects. In 2019, the same ... team that has led this study described the essential function of E93 to complete metamorphosis in insects and initiate the maturation of the tissues that go on to form the adult. However, the gene responsible for determining the juvenile stage was unknown until now. This study has now identified the Chimno gene as the main precursor of this stage in insects. ...
By deleting the Chinmo gene in Drosophila specimens, the scientists observed that these insects progressed to the pupal stage without completing the juvenile stage, moving to the adult stage early. ...
Chinmo and Br-C belong to the large family of BTB-ZF transcription factors—proteins involved in cancer and that are also found in humans. Although previous studies had shown that Chinmo is a precursor of cancer, the role of Br-C and E93 in this disease was unknown until now. ...
The study shows that while Chinmo is an oncogenic precursor because it promotes tissue growth and prevents differentiation, C-Br and E93 serve as tumor suppressors by activating tissue maturation. ...
The results of the study indicate that the regulatory action of Chinmo and E93 in more basal insects such as the cockroach are sufficient to determine the transition from the juvenile to the adult form. However, the introduction of the Br-C gene allowed the development of the pupae and the appearance of complete metamorphosis through a new pupal stage in insects such as flies. ..."
From the abstract:
"During development, the growing organism transits through a series of temporally regulated morphological stages to generate the adult form. ... The identity of the larval, pupal and adult stages depends on the sequential expression of the transcription factors chinmo, Br-C and E93. However, how these transcription factors determine temporal identity in developing tissues is poorly understood. Here we report on the role of the larval specifier chinmo in larval and adult progenitor cells during fly development. Interestingly, chinmo promotes growth in larval and imaginal tissues in a Br-C-independent and -dependent manner, respectively. In addition, we found that the absence of chinmo during metamorphosis is critical for proper adult differentiation. Importantly, we also provide evidence that, in contrast to the well-known role of chinmo as a pro-oncogene, Br-C and E93 act as tumour suppressors. Finally, we reveal that the function of chinmo as a juvenile specifier is conserved in hemimetabolous insects as its homolog has a similar role in Blatella germanica. Taken together, our results suggest that the sequential expression of the transcription factors Chinmo, Br-C and E93 during larva, pupa an adult respectively, coordinate the formation of the different organs that constitute the adut organism."
Chinmo, “the youth gene” (primary news source) Researchers discover Chimno, the gene responsible for the juvenile stage in insects. This gene is present in mammals and could play a key role in cancerous processes.
Antagonistic role of the BTB-zinc finger transcription factors chinmo and broad-complex in the juvenile/pupal transition and in growth control (manuscript version, PDF is downloadable)
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