Saturday, January 15, 2022

What’s next for lab-grown human embryos?

Recommendable! The 14-day rule dates back to 1979, an eternity in terms of far we have come since then. Why is it so controversial to grow a human embryo in the laboratory? Do the benefits of studying early human development not far outweigh the risks?

Fears of Frankenstein etc. are probably overblown!

Foolish countries like Germany (otherwise known for its ridiculous commitment to the Climate Change religion and the sudden abandoning of nuclear power) prohibit human embryo research entirely.

"... In May, the International Society for Stem Cell Research (ISSCR) released new guidelines1 that relaxed the 14-day rule, taking away the hard barrier. Although only a few labs around the world have perfected the techniques needed to culture human embryos up to day 14, the science is advancing rapidly. The relaxed rule allows lab groups, in countries where it is legal, to apply to the regulators for permission to continue research past 14 days. Such studies could reveal what happens during human development after the embryo would normally have implanted in the uterus, about a week after fertilization. It then goes through a stage called gastrulation, roughly between days 14 and 22, when the body’s main pattern emerges and the foundations are laid for organ generation. ...
The 14-day rule was first proposed in 1979, as IVF technology emerged and human embryos existed for the first time outside the body — although the longest they could survive at the time was a few days. By 2006, when the ISSCR issued its first set of guidelines for human embryonic stem cells (ES cells), the 14-day rule was firmly established in the research community. ...
In several countries, including Germany and Austria, it is illegal to do any research on human embryos, and many others impose a 14-day limit by law, such as the United Kingdom, China, Japan, Australia and Canada. In a few places, including the United States and Israel, there are guidelines but no law prohibiting or limiting human embryo research, although it cannot be federally funded in the United States. ...
Researchers working with animal embryos have already cultured them beyond the developmental equivalent of 14 days, which could pave the way for similar advances in human embryo culture. In March, Jacob Hanna’s group at the Weizmann Institute of Science in Rehovot, Israel, doubled the time that mouse embryos can be cultured in the laboratory, from day 5.5 to day 11 (roughly equivalent to human days 13 to 30). ..."

What’s next for lab-grown human embryos?



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