Good news! And what a massive hunt for clues!
"... Now, a study that combed data from regular blood tests of 10 million U.S. soldiers has found the strongest evidence yet that infection with a common virus, Epstein-Barr virus (EBV), dramatically increases a person’s chances of developing the rare disease. ...
A combination of genetics—the disease often runs in families—and environmental triggers such as viruses is the likely cause. EBV, a herpesvirus that infects most people by adolescence and then lies latent in B cells throughout life, has long been a prime suspect. ..."
A combination of genetics—the disease often runs in families—and environmental triggers such as viruses is the likely cause. EBV, a herpesvirus that infects most people by adolescence and then lies latent in B cells throughout life, has long been a prime suspect. ..."
"... There is no treatment or prophylactic for EBV, although Moderna is developing an mRNA vaccine for EBV using the same technology employed for their COVID serums. Earlier this year, Moderna started trials for this EBV vaccine with human volunteers. ...
Individuals who contracted EBV later in life and reported infectious mononucleosis are much more likely to develop MS in their lifetime compared to the majority of people who are first infected with EBV in the first few years of life. Furthermore, MS patients who have undergone cell depletion therapies have seen their symptoms improve. These are the same cells that the Epstein-Barr virus latently infects, strengthening the link between the virus and MS. ..."
Individuals who contracted EBV later in life and reported infectious mononucleosis are much more likely to develop MS in their lifetime compared to the majority of people who are first infected with EBV in the first few years of life. Furthermore, MS patients who have undergone cell depletion therapies have seen their symptoms improve. These are the same cells that the Epstein-Barr virus latently infects, strengthening the link between the virus and MS. ..."
From the abstract:
"Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom were diagnosed with MS during their period of service. Risk of MS increased 32-fold after infection with EBV but was not increased after infection with other viruses, including the similarly transmitted cytomegalovirus. Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS."
Multiple sclerosis may be caused by virus that infects 9 in 10 people A herpes virus that is more known for causing "the kissing disease" may also be responsible for multiple sclerosis.
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