Good news! "The research indicates that these findings could be instrumental in developing drugs to directly change the neural processes in the cerebellum and offer hope for effective medications for the main symptoms of autism in the future."
"Recent years have provided substantial research displaying the effect of genetic mutations on the development of autism and other neurodevelopmental disorders. Based on those studies, researchers have focused attention on the commonalities behind those mutations and how they impact on the functioning of the brain. ...
Upon further investigation, the research team also observed that the genetic mutation affected the proliferation of cells in the brain and inhibited the production of new neurons. ..."
Upon further investigation, the research team also observed that the genetic mutation affected the proliferation of cells in the brain and inhibited the production of new neurons. ..."
"Several genes implicated in autism spectrum disorder (ASD) are chromatin regulators, including POGZ. ...
We demonstrate that Pogz deficient mice show microcephaly, growth impairment, increased sociability, learning and motor deficits, mimicking several of the human symptoms. ..."
We demonstrate that Pogz deficient mice show microcephaly, growth impairment, increased sociability, learning and motor deficits, mimicking several of the human symptoms. ..."
Here is the underlying research paper:
Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice (open access, published November 2020)
The research team:
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