SARS-CoV-2 Protein Hampers Innate Immune Reaction In Vitro

Recommendable! Well written and detailed! This seems to be some promising research to understand how SARS Cov-2 operates and how to defeat it!



"SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant. ... One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS-CoV-2 ORF3b is a potent interferon antagonist, suppressing the induction of type I interferon more efficiently than its SARS-CoV ortholog. Phylogenetic analyses and functional assays revealed that SARS-CoV-2-related viruses from bats and pangolins also encode truncated ORF3b gene products with strong anti-interferon activity. ..." so the title and abstract of the BioArXiv paper.



SARS-CoV-2 Protein Hampers Innate Immune Reaction In Vitro | The Scientist Magazine® The viral protein known as ORF3b limits the induction of the type I interferon response, which typically alerts other immune system components to the presence of a virus, in cultured cells.