Experimental compound shown to block effects of multiple harmful or even deadly drugs

Very good news! This sounds almost like wonder drug! Hopefully, this will also help to prevent e.g. accidental or involuntary drug overdose in the future.

However, the practical obstacles at this point seem daunting. The medication has to be injected within minutes of drug consumption.

"... Known as Pillar[6]MaxQ (P6AS), the chemical was first announced in 2020. ...

P6AS is a type of "molecular container" chemical compound. Once injected into the bloodstream, it binds with the molecules of certain other compounds and sequesters them into its central cavity, where they're surrounded by an outer layer of water. Doing so alters their chemical, physical and biological qualities, blocking their effects on the body.

In tests performed on lab mice, P6AS proved to be highly effective at mitigating the effects of fentanyl – which is an opioid – but also on methamphetamine, which is not. ...
The captured drug molecules were subsequently passed in the urine – a process which P6AS may also facilitate. ...
It should be noted that in the case of methamphetamine dosing, P6AS had to be injected within five minutes in order to be effective. In most real-world scenarios, that would likely be too small of a window. When it came to fentanyl, however, P6AS worked when injected up to 15 minutes after the opioid was administered. ..."

"... In vitro and in vivo laboratory tests showed that P6AS successfully sequestered fentanyl and methamphetamine, a non-opioid stimulant, and mitigated their potentially deadly biological effects. Additional in vitro tests revealed that P6AS also binds strongly to other drugs, including PCP, ecstasy and mephedrone, which suggests that P6AS could someday be used to counteract a wide array of drugs.  ...
Unlike naloxone, which stops a drug of abuse from binding to receptors in the brain, [P6AS] molecular container targets drugs directly in the bloodstream. ...
[Researcher] believes that the excretion of fentanyl [through urine] could help prevent this phenomenon, known as renarcotization. ..."

From the highlights and abstract:

"Highlights

• Pillar[6]MaxQ binds tightly to fentanyl, meth, PCP, MDMA, and mephedrone in water

• Pillar[6]MaxQ displays good biocompatibility according to in vitro and in vivo assays

• The in vivo hyperlocomotive effects of meth (fentanyl) can be reversed by Pillar[6]MaxQ

• Pillar[6]MaxQ has significant potential as a broad-spectrum in vivo sequestrant

Summary

Pillar[6]MaxQ (P6AS) functions as an in vivo sequestration agent for methamphetamine and fentanyl. We use 1H NMR, isothermal titration calorimetry, and molecular modeling to deduce the geometry and strength of the P6AS-drug complexes. P6AS forms tight complexes with fentanyl (Kd = 9.8 nM), PCP (17.1 nM), MDMA (25.5 nM), mephedrone (52.4 nM), and methamphetamine (101 nM). P6AS has good in vitro biocompatibility according to MTS metabolic, adenylate kinase cell death, and hERG ion channel inhibition assays, and the Ames fluctuation test. The no observed adverse effect level for P6AS is 45 mg/kg. The hyperlocomotion of mice treated with methamphetamine (0.5 mg/kg) can be ameliorated by treatment with P6AS (35.7 mg/kg) 5 min later, whereas the hyperlocomotion of mice treated with fentanyl (0.1 mg/kg) can be controlled by treatment with P6AS (5 mg/kg) up to 15 min later.  ..."

Experimental compound shown to block effects of multiple harmful drugs When someone overdoses on opioid drugs, a medication called naloxone can save their life by quickly mitigating the effects of the narcotics. A new chemical shows promise for serving a similar role, but it also works on non-opioid drugs.

UMD Scientists Create Chemical Compound That Can Reverse Effects of Potentially Deadly Drugs Their method successfully counteracted two highly addictive drugs—fentanyl and methamphetamine—in lab experiments

Pillar[6]MaxQ: A potent supramolecular host for in vivo sequestration of methamphetamine and fentanyl (no public access)

Graphical abstract