Recommendable! What little we still know about the inner workings of cells! Amazing stuff!
However, since the climate catastrophe is imminent so we are told by daily propaganda and demagoguery, we may not be able to do more research! (Caution: Irony! Global Warming is a hoax and Climate Change is a religion)
"Once thought to be little more than blobs of fat inside [mammalian] eukaryotic cells, lipid droplets may in fact provide a first line of defence against invading pathogens ..."
Full abstract:
"Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection."
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense (no public access, but lots of information is provided)
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