Amazing stuff!
"A reaction between 2 simple molecules might be the secret to uncovering how the building blocks of life were first encapsulated in a cell membrane, according to new research. ..."
From the abstract:
"All known forms of life are composed of cells, whose boundaries are defined by lipid membranes that separate and protect cell contents from the environment. It is unknown how the earliest forms of life were compartmentalized.
Several models have suggested a role for single-chain lipids such as fatty acids, but the membranes formed are often unstable, particularly when made from shorter alkyl chains (≤C8) that were probably more prevalent on prebiotic Earth.
Here we show that the amino acid cysteine can spontaneously react with two short-chain (C8) thioesters to form diacyl lipids, generating protocell-like membrane vesicles. The three-component reaction takes place rapidly in water using low concentrations of reactants. Silica can catalyse the formation of protocells through a simple electrostatic mechanism. Several simple aminothiols react to form diacyl lipids, including short peptides. The protocells formed are compatible with functional ribozymes, suggesting that coupling of multiple short-chain precursors may have provided membrane building blocks during the early evolution of cells."
On the Origin of Life: How the First Cell Membranes Came to Exist (original news release) "New research provides a possible explanation on the development of early Earth protocells"
Protocells by spontaneous reaction of cysteine with short-chain thioesters (no public access)
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