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"A new study ... maps the cellular and molecular dynamics of human wound healing in exceptional detail. ...
They used advanced single-cell RNA sequencing and spatial transcriptomics techniques to track how cells and molecules change over time.
"We have discovered that an important protein, FOSL1, helps skin cells to move and cover wounds during the healing process. We have also seen that certain other cells, such as macrophages and fibroblasts, help these skin cells to move and repair the damage," ...
"When we compared wounds from people with chronic diseases, such as venous ulcers and diabetic foot ulcers, we found that problems with cell movement can make healing more difficult," ..."
"Self-healing of wounds is vital, but little is known about how cells cooperate during this process. To better understand this, researchers studied skin and wounds from the same individuals at different phases of healing: inflammation, proliferation, and remodeling. ...
This breakthrough sheds light on why some wounds fail to heal effectively. Through a detailed comparison between chronic and acute wounds, the researchers uncovered impaired inflammatory responses and cellular migration capability, suggesting targeted approaches to overcome these healing barriers. ..."
From the highlights and abstract:
"Highlights
• A spatiotemporal atlas to explore human in vivo gene expression across wound healing
• Wound margin architecture unveils a model for human re-epithelialization
• Distinct healing challenges in venous ulcers and diabetic foot ulcers
• Unique human healing traits emerge in cellular heterogeneity and gene expression
Summary
Wound healing is vital for human health, yet the details of cellular dynamics and coordination in human wound repair remain largely unexplored. To address this, we conducted single-cell multi-omics analyses on human skin wound tissues through inflammation, proliferation, and remodeling phases of wound repair from the same individuals, monitoring the cellular and molecular dynamics of human skin wound healing at an unprecedented spatiotemporal resolution. This singular roadmap reveals the cellular architecture of the wound margin and identifies FOSL1 as a critical driver of re-epithelialization. It shows that pro-inflammatory macrophages and fibroblasts sequentially support keratinocyte migration like a relay race across different healing stages. Comparison with single-cell data from venous and diabetic foot ulcers uncovers a link between failed keratinocyte migration and impaired inflammatory response in chronic wounds. Additionally, comparing human and mouse acute wound transcriptomes underscores the indispensable value of this roadmap in bridging basic research with clinical innovations."
New study reveals new insights into wound healing (original news release) "A new study from Karolinska Institutet maps the cellular and molecular dynamics of human wound healing in exceptional detail. The study was published in Cell Stem Cell."
Graphical abstract
Figure 1. A spatiotemporal map of human skin wound healing
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