Good news, but old news!
This popular science article is annoying for at least three typical reasons:
- It does not contain a link to any original press release
- It does not contain any link to a research paper published in a journal
- The lazy author failed to inform the reader that this research was already published two years ago on bioRxiv!
"Researchers ... have discovered the gene, called Zeb2, that proliferates in autoimmunity diseases like the painful and debilitating inflammations of lupus, rheumatoid arthritis, Crohn’s disease and ulcerative colitis.
Zeb2 controls the immune system’s Atypical B cells (ABC).
The discovery was made in a slightly off-beat way — by giving mice malaria. ...
Researchers compared the responses of mice to malaria, in strains of animals with and without the capacity to make ABCs in response to the infection. The gene for ABC production was identified as ‘Zeb2’, and switched off in half the test mice using Crisper Cas9’s molecular scissors. ..."
ZEB2 regulates the development of CD11c+ atypical B cells (bioRxiv, published September 2022)
Zeb2 drives the formation of CD11c+ atypical B cells to sustain germinal centers that control persistent infection (no public access, published February 2024)
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