Wednesday, June 21, 2023

Daytime naps may be good for our brains, study says

I wholeheartedly nap to that! 😊 As usual moderation is the key! Napping too much or too long may not be so good!

"... Habitual napping was linked with larger total brain volume, which is associated with a lower risk of dementia and other diseases, according to researchers ...
On average, the difference in brain volume between nappers and non-nappers was equivalent to 2.5 to 6.5 years of aging, researchers said. ..."

From the highlights and abstract:
"Highlights
• Whether daytime napping is causally associated with brain health remains elusive.
• We studied the causal role of daytime napping on cognitive and neuroimaging outcomes.
• We found a modest causal link between habitual napping and larger total brain volume.
Abstract
Objectives
Daytime napping has been associated with cognitive function and brain health in observational studies. However, it remains elusive whether these associations are causal. Using Mendelian randomization, we studied the relationship between habitual daytime napping and cognition and brain structure.
Methods
Data were from UK Biobank (maximum n = 378,932 and mean age = 57 years). Our exposure (daytime napping) was instrumented using 92 previously identified genome-wide, independent genetic variants (single-nucleotide polymorphisms, SNPs). Our outcomes were total brain volume, hippocampal volume, reaction time, and visual memory. Inverse-variance weighted was implemented, with sensitivity analyses (Mendelian randomization-Egger and Weighted Median Estimator) for horizontal pleiotropy. We tested different daytime napping instruments to ensure the robustness of our results.
Results
Using Mendelian randomization, we found an association between habitual daytime napping and larger total brain volume (unstandardized ß = 15.80 cm3 and 95% CI = 0.25; 31.34) but not hippocampal volume (ß = −0.03 cm3 and 95% CI = −0.13;0.06), reaction time (expß = 1.01 and 95% CI = 1.00;1.03), or visual memory (expß = 0.99 and 95% CI = 0.94;1.05). Additional analyses with 47 SNPs (adjusted for excessive daytime sleepiness), 86 SNPs (excluding sleep apnea), and 17 SNPs (no sample overlap with UK Biobank) were largely consistent with our main findings. No evidence of horizontal pleiotropy was found.
Conclusions
Our findings suggest a modest causal association between habitual daytime napping and larger total brain volume. Future studies could focus on the associations between napping and other cognitive or brain outcomes and replication of these findings using other datasets and methods."

Daytime naps may be good for our brains, study says | CNN

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