Good news! Cancer is history (soon)!
"... Scientists have now demonstrated a new potential cancer vaccine that involves injections of dormant tumor cells to stimulate the immune system and help prevent the onset of cancer. ...
Now, scientists at the Institute for Research in Biomedicine (IRB) Barcelona have developed a new type of cancer vaccine. Previous versions have been designed to stimulate the immune response by administering dead tumor cells, but in the new study the team found more success using cancer cells in a dormant state known as senescence. ...
The team also administered the senescent cell vaccines to mice that already had developed tumors, and found some improvements there too, albeit not to the same extent as the prophylactic treatment. ..."
Now, scientists at the Institute for Research in Biomedicine (IRB) Barcelona have developed a new type of cancer vaccine. Previous versions have been designed to stimulate the immune response by administering dead tumor cells, but in the new study the team found more success using cancer cells in a dormant state known as senescence. ...
The team also administered the senescent cell vaccines to mice that already had developed tumors, and found some improvements there too, albeit not to the same extent as the prophylactic treatment. ..."
"Researchers at IRB Barcelona report that the induction of senescence in tumour cells strongly stimulates the immune system.
Vaccination with senescent cells significantly reduces the development of tumours in experimental models of melanoma and pancreatic cancer. ..."
From the abstract:
"Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of interferon signaling, enhanced MHC class I machinery, and presentation of senescence-specific self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong anti-tumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells undergoing immunogenic cell death. Finally, the induction of senescence in human primary cancer cells also augments their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. Our study indicates that senescent cancer cells can be exploited to develop efficient and protective CD8-dependent anti-tumor immune responses."
Immune cells infiltrate (deep red) senescent cancer cells (light blue)
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