Good news!
"... To answer these questions, Kapoor and his team looked at genetic data from about 700,000 families involved in the NIAAA’s Collaborative Studies on the Genetics of Alcoholism (COGA), as well as genetic variants and surveys about drinks per week from the UK Biobank dataset, then compared those to data from analyses of adult and fetal brains that determined how much RNA was transcribed from particular genes, and which genes were epigenetically silenced or expressed.
This multi-omic approach enabled the researchers to map to the level of changes in a single base pair ...
While the study’s meta-analysis of mutations revealed many genes associated with alcohol use, the team zeroed in on two genes associated with high alcohol consumption (measured in drinks per week), SPI1 and MAPT, because previous studies had linked them to neurodegenerative diseases. ..."
While the study’s meta-analysis of mutations revealed many genes associated with alcohol use, the team zeroed in on two genes associated with high alcohol consumption (measured in drinks per week), SPI1 and MAPT, because previous studies had linked them to neurodegenerative diseases. ..."
"... In this study, we use multi-omics approaches, to fine-map AUD [alcohol used disorder] and DPW [drinks per week] associations at single SNP resolution to demonstrate that rs56030824 on chromosome 11 significantly reduces SPI1 mRNA expression in myeloid cells and lowers risk for AUD and DPW. Our analysis also identifies MAPT as a candidate causal gene specifically associated with DPW. Genes prioritized in this study show overlap with causal genes associated with neurodegenerative disorders. ..."
No comments:
Post a Comment