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"... The study is the first to demonstrate that mechanical forces can influence cellular growth and differentiation in the bone marrow, according to the authors, and provides a possible new explanation for how exercise strengthens bones and the immune system. ...
His latest work counters the insulation theory and shows that arteriolar blood vessels that go through the bone surface to the marrow transmit movement-induced mechanical forces and thereby stimulate the proliferation of bone- and immune-cell precursors. ...
His latest work counters the insulation theory and shows that arteriolar blood vessels that go through the bone surface to the marrow transmit movement-induced mechanical forces and thereby stimulate the proliferation of bone- and immune-cell precursors. ...
They found that older mice that ran on a wheel produced more osteolectin and more new bone cells compared with older mice that didn’t run. Additionally, the researchers found that as the bone cells grew, they secreted growth factors that encouraged the formation of immune cells, which improved the animals’ ability to fight off bacterial infections. ...
The results shed light on so-called stem cell niches—specialized environments in the bone marrow that are controlled by growth factors. Very few of the bone marrow’s niches have been studied in depth. ..."
The results shed light on so-called stem cell niches—specialized environments in the bone marrow that are controlled by growth factors. Very few of the bone marrow’s niches have been studied in depth. ..."
Here is the link to the referenced paper:
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