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"The production of endogenous hydrogen sulfide (H2S) has been shown to confer antibiotic tolerance in all bacteria studied to date. Therefore, this mediator has been speculated to be a universal defense mechanism against antibiotics in bacteria. ... In this study, we established that the pathogenic bacteria Acinetobacter baumannii does not produce endogenous H2S, giving us the opportunity to test the effect of exogenous H2S on antibiotic tolerance in a bacterium that does not produce it. ... we demonstrated that instead of conferring antibiotic tolerance, exogenous H2S sensitized A. baumannii to multiple antibiotic classes, and was able to revert acquired resistance to gentamicin."
"Researchers from the Singapore-MIT Alliance for Research and Technology (SMART), MIT's research enterprise in Singapore, tested this concept on Acinetobacter baumanii ..."
‘Hydrogen sulphide may reverse drug resistance’ - SciDev.Net South-East Asia & Pacific Hydrogen sulphide (H2S) can reverse drug resistance in some bacteria
It was originally thought that H2S helps bacteria against antibiotics
With the finding combination therapies involving H2S are a possibility
Here is the link to the underlying research paper (open access):
Hydrogen Sulfide Sensitizes Acinetobacter baumannii to Killing by Antibiotics
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