Tuesday, March 17, 2020

Newly discovered ‘magic methyl’ reaction could turbocharge the potency of some drugs

Very recommendable! This could be a major breakthrough!

"For years, drug discovery chemists have struggled to streamline a process that can boost a drug’s potency up to 2000-fold: “magic methylation.” The reaction [replaces] single hydrogen atoms and replaces them with methyl groups—reshaping the drug molecule to more easily interact with its biological targets. ... Adding further difficulty, C-H bonds are among the strongest in organic molecules, which makes it harder to target just one bond without affecting others"

Newly discovered ‘magic methyl’ reaction could turbocharge the potency of some drugs | Science | AAAS: “Dream reaction” could lead to new therapies with fewer side effects

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