Toxic lover: Genetically engineering males to have venomous semen to kill disease-carrying females

Very clever! Femicide for dangerous insects.

Is there a good reason why not to eradicate bloodsucker from this Earth?

"... Now, researchers have found a way to up the efficiency: Instead of males’ semen lacking viable sperm, it contains lethal toxins from a venomous animal.

When researchers tested the approach on fruit flies, they found that toxins from anemones and Brazilian wandering spiders were most effective, reducing the median lifespans of mated female flies by up to 64%. Additional modeling they performed suggested such mortality would reduce female mosquito populations faster than other approaches and lower blood feeding by as much as 60%. ..."

From the abstract:

"The emergence of insecticide resistance has increased the need for alternative pest management tools. Numerous genetic biocontrol approaches, which involve the release of genetically modified organisms to control pest populations, are in various stages of development to provide highly targeted pest control. However, all current mating-based genetic biocontrol technologies function by releasing engineered males which skew sex-ratios or reduce offspring viability in subsequent generations which leaves mated females to continue to cause harm (e.g. transmit disease).

Here, we demonstrate intragenerational genetic biocontrol, wherein mating with engineered males reduces female lifespan. The toxic male technique (TMT) involves the heterologous expression of insecticidal proteins within the male reproductive tract that are transferred to females via mating. In this study, we demonstrate TMT in Drosophila melanogaster males, which reduce the median lifespan of mated females by 37 − 64% compared to controls mated to wild type males. Agent-based models of Aedes aegypti predict that TMT could reduce rates of blood feeding by a further 40 – 60% during release periods compared to leading biocontrol technologies like fsRIDL. TMT is a promising approach for combatting outbreaks of disease vectors and agricultural pests."

ScienceAdviser

Recombinant venom proteins in insect seminal fluid reduce female lifespan

Fig. 1: Intergenerational vs intragenerational genetic biocontrol of pest insects.