Good news! Cancer is history (soon)!
"Speckle signature divines cancer’s future
It’s possible to predict whether a person will survive kidney cancer by analysing the ‘speckle signature’ of their tumour cells. Speckles are structures inside the nucleus of a cell that are stuffed full of proteins involved in RNA processing. Researchers measured the expression of 117 proteins from speckles inside kidney cancer cells and identified two distinct signatures that had a “remarkable correlation with patient outcomes”. People with kidney cancer who had speckle Signature I had worse outcomes than those with speckle Signature II."
From the abstract:
"Nuclear speckles are dynamic nuclear bodies characterized by high concentrations of factors involved in RNA production. Although the contents of speckles suggest multifaceted roles in gene regulation, their biological functions are unclear.
Here we investigate speckle variation in human cancer, finding two main signatures. One speckle signature was similar to healthy adjacent tissues, whereas the other was dissimilar, and considered an aberrant cancer speckle state. Aberrant speckles show altered positioning within the nucleus, higher levels of the TREX RNA export complex and correlate with poorer patient outcomes in clear cell renal cell carcinoma (ccRCC), a cancer typified by hyperactivation of the HIF-2α transcription factor. We demonstrate that HIF-2α promotes physical association of certain target genes with speckles depending on HIF-2α protein speckle-targeting motifs, defined in this study. We identify homologous speckle-targeting motifs within many transcription factors, suggesting that DNA-speckle targeting may be a general gene regulatory mechanism. Integrating functional, genomic and imaging studies, we show that HIF-2α gene regulatory programs are impacted by speckle state and by abrogation of HIF-2α-driven speckle targeting.
These findings suggest that, in ccRCC, a key biological function of nuclear speckles is to modulate expression of select HIF-2α-regulated target genes that, in turn, influence patient outcomes. Beyond ccRCC, tumour speckle states broadly correlate with altered functional pathways and expression of speckle-associated gene neighbourhoods, exposing a general link between nuclear speckles and gene expression dysregulation in human cancer."
Nuclear speckles regulate functional programs in cancer (no public access, but article above contains link to PDF file)
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