Saturday, May 06, 2023

Wuhan sea food wholesale market samples fail to shed further light on COVID origins

Be my guest, go ahead eliminating all explanations until the lab leak hypothesis becomes the most plausible and finally deserves to be fully investigated!

Why is the world still rather clueless about the origin of the global SARS-CoV-2/Covid-19 pandemic? The Communist Party of China did a superb job to cover it up!


The U.S. is complicit in so far as it financed and supported so-called gain of function research at the Wuhan Institute of Virology in circumvention of specific U.S. regulations governing such research! Not least for this reason alone the West did very poorly to investigate the origin!


"Samples collected at the Huanan Seafood Wholesale Market in Wuhan, China, in the early weeks of the COVID-19 pandemic are of limited value for pinpointing which animal species — if any — infected people at the market, according to a new analysis.
Two previous analyses of the data described genetic material from various wild animals, suggesting it was possible that these animals could have passed the virus to people at the market. The new analysis attempts to identify the specific animal responsible for the spillover — but comes up empty. ...
that frozen animal carcasses or blood samples collected from people in late 2019 could hold some answers if any such samples exist. ..."

From the abstract:
"The role of the Huanan Seafood Market in the early SARS-CoV-2 outbreak remains unclear. Recently the Chinese CDC released data from deep sequencing of environmental samples collected from the market after it was closed on January-1-2020 (Liu et al. 2023a). Prior to this release, Crits-Christoph et al. (2023) analyzed data from a subset of the samples. Both studies concurred that the samples contained genetic material from a variety of species, including some like raccoon dogs that are susceptible to SARS-CoV-2. However, neither study systematically analyzed the relationship between the amount of genetic material from SARS-CoV-2 and different animal species. Here I implement a fully reproducible computational pipeline that jointly analyzes the number of reads mapping to SARS-CoV-2 and the mitochondrial genomes of chordate species across the full set of samples. I validate the presence of genetic material from numerous species, and calculate mammalian mitochondrial compositions similar to those reported by Crits-Christoph et al. (2023). However, the number of SARS-CoV-2 reads is not consistently correlated with reads mapping to non-human susceptible species. For instance, 14 samples have >20% of their chordate mitochondrial material from raccoon dogs, but only one of these samples contains any SARS-CoV-2 reads, and that sample only has 1 of ∼200,000,000 reads mapping to SARS-CoV-2. Instead, SARS-CoV-2 reads are most correlated with reads mapping to various fish, such as catfish and largemouth bass. These results suggest that while metagenomic analysis of the environmental samples is useful for identifying animals or animal products sold at the market, co-mingling of animal and viral genetic material is unlikely to reliably indicate whether any animals were infected by SARS-CoV-2."

Wuhan market samples fail to shed further light on COVID origins New analysis of genomic data from market swabs highlights their limitations.




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