Amazing stuff! Cancer is history!
"Not only do killer T cells spew toxic sludge onto cancer cells: they can also destroy cancer by physically crushing it. Researchers witnessed killer T cells latching onto cell-sized microparticles and forming a compressive crater. This kind of physical force would break a cancer cell’s cytoskeleton and cause its contents to spill out. “These findings demonstrate that immune cells exert specialized patterns of force on their targets to carry out distinct immunological functions,” ..."
The following abstract is awfully written, way too much jargon and fuzziness! Which actually raises some doubts!
From the editor's summary and abstract:
"Editor’s summary
Immune cells apply mechanical forces to their surrounding environment, but whether their biomechanical output is tuned to support distinct immunological functions remains unclear. Using super-resolution traction force microscopy, de Jesus et al. compared the patterns of interfacial forces exerted by cytotoxic T lymphocytes (CTLs) with other immune cells. Within the immune synapse, CTLs formed a complex compressive crater, a biomechanical signature that was distinct from those of macrophages initiating phagocytosis and T cells engaging in nonlytic interactions. These findings demonstrate that immune cells exert specialized patterns of force on their targets to carry out distinct immunological functions. ...
Abstract
Immune cells have intensely physical lifestyles characterized by structural plasticity and force exertion. To investigate whether specific immune functions require stereotyped mechanical outputs, we used super-resolution traction force microscopy to compare the immune synapses formed by cytotoxic T cells with contacts formed by other T cell subsets and by macrophages. T cell synapses were globally compressive, which was fundamentally different from the pulling and pinching associated with macrophage phagocytosis. Spectral decomposition of force exertion patterns from each cell type linked cytotoxicity to compressive strength, local protrusiveness, and the induction of complex, asymmetric topography. These features were validated as cytotoxic drivers by genetic disruption of cytoskeletal regulators, live imaging of synaptic secretion, and in silico analysis of interfacial distortion. Synapse architecture and force exertion were sensitive to target stiffness and size, suggesting that the mechanical potentiation of killing is biophysically adaptive. We conclude that cellular cytotoxicity and, by implication, other effector responses are supported by specialized patterns of efferent force."
Killer immune cells pile on the pressure to slay their foes (no public access) Immune-system assassins called killer T cells compress target cells, forming a destructive crater.
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity (no public access)
T cells (small, rounded objects; artificially coloured) attack a cancer cell. Killer T cells break the inner structure of target cells.
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