Amazing stuff! Cancer is history (soon)!
"[The teenager] was diagnosed with T cell leukemia in mid-2021, and after exhausting all current therapies was on her way to palliative care. Now, six months after the experimental treatment, she is still in full remission. ...
The patient's incurable leukemia was effectively cleared using "base-edited" immune T-cells from a donor. ...
The technology behind the innovative new treatment is barely five years old, with researchers originally describing the technique as "CRISPR 2.0." Unlike prior CRISPR gene editing techniques, which act essentially like cut-and-paste tools, base editing is much more targeted and precise. ...
In this new instance, base editing was utilized to create a novel treatment for a 13-year-old patient suffering T-cell acute lymphoblastic leukemia. This incurable form of cancer involves a patient's T cells not maturing effectively and disrupting other blood cells. ...
The patient's incurable leukemia was effectively cleared using "base-edited" immune T-cells from a donor. ...
The technology behind the innovative new treatment is barely five years old, with researchers originally describing the technique as "CRISPR 2.0." Unlike prior CRISPR gene editing techniques, which act essentially like cut-and-paste tools, base editing is much more targeted and precise. ...
In this new instance, base editing was utilized to create a novel treatment for a 13-year-old patient suffering T-cell acute lymphoblastic leukemia. This incurable form of cancer involves a patient's T cells not maturing effectively and disrupting other blood cells. ...
The base edits altered several key markers that identify the immune cells as T cells. This meant the edited cells were essentially invisible to other T cells.
Other base edits to the T cells removed markers that were unique to the donor, turning the cells into a "universal" treatment. ...
Within a month of receiving the experimental therapy the patient, named Alyssa, was completely leukemia free. Now, six months later, Alyssa is still in complete remission. ...
The preliminary clinical trial is looking to enroll another 10 patients over the coming years but this leukemia treatment is just the tip of the iceberg for base editing technology. At least three other trials are already underway testing base editing to treat sickle-cell anemia, high cholesterol and a blood disorder called beta-thalassemia. ..."
Within a month of receiving the experimental therapy the patient, named Alyssa, was completely leukemia free. Now, six months later, Alyssa is still in complete remission. ...
The preliminary clinical trial is looking to enroll another 10 patients over the coming years but this leukemia treatment is just the tip of the iceberg for base editing technology. At least three other trials are already underway testing base editing to treat sickle-cell anemia, high cholesterol and a blood disorder called beta-thalassemia. ..."
"... She was treated with all current conventional therapies for her blood cancer, including chemotherapy and a bone marrow transplant, but unfortunately her disease came back and there were no further treatment options. ..."
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