Good news!
"... [researchers] figured out that the element [manganese] can bind to a complex needed by lipoproteins, chemical carriers that move lipids including cholesterol and triglycerides, into the bloodstream. This complex known as the coat protein complex II (COPII) needs to maintain a very precise chemical balance that the manganese disrupts. As a result of this disruption, the researchers found that in the mice they studied, even oral manganese dramatically reduced blood concentration of lipids and removed plaques that had been established in the rodents' blood vessels. ..."
From what is believed to be the abstract:
"Precise control of circulating lipid levels is vital in both health and disease. We recently uncovered that bulk lipids, transported by lipoproteins, enter the circulation initially via the coat protein complex II (COPII) in a condensation-dependent manner. Divalent manganese, acting as a signaling messenger, selectively controls COPII condensation to regulate lipid homeostasis in vivo. Here we present evidence for a manganese-based therapy in murine models of hypolipidemia and hyperlipidemia, aided by advanced in vivo multimodal imaging of atherosclerosis. Dietary titration of manganese supply enables tailored control of circulating lipid levels in whole animals, with no apparent toxicity. Strikingly, elevating the manganese signal through diets could not only effectively treat pathological hyperlipidemia, but further achieve significant reversal of atherosclerotic plaques. Hence, the study provides critical proof-of-principle for a novel therapy for deadly cardiovascular diseases with a potentially broad impact"
No comments:
Post a Comment