Good news! Exercise more! Irisin sounds like music! It was only discovered in 2012. The researchers also have show that injection of irisin may help.
"... In 2012 a team of researchers from Harvard Medical School published a landmark study reporting the discovery of a new hormone released by muscles during exercise. The researchers named the hormone irisin. ...
By 2015 the argument was ultimately settled, with new research affirming irisin is real and secreted by skeletal muscles in humans during exercise. ...
A 2019 mouse study found boosting irisin levels in Alzheimer’s animal models improved brain plasticity and memory. ..."
By 2015 the argument was ultimately settled, with new research affirming irisin is real and secreted by skeletal muscles in humans during exercise. ...
A 2019 mouse study found boosting irisin levels in Alzheimer’s animal models improved brain plasticity and memory. ..."
"Researchers from Johns Hopkins Medicine and the Dana Farber Cancer Institute in Boston have shown that a hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson’s disease and halts movement problems in mice. ..."
From the abstract:
"Physical activity provides clinical benefit in Parkinson’s disease (PD). Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced neurodegeneration in the α-syn preformed fibril (PFF) mouse model of sporadic PD. Intravenous delivery of irisin via viral vectors following the stereotaxic intrastriatal injection of α-syn PFF cause a reduction in the formation of pathologic α-syn and prevented the loss of dopamine neurons and lowering of striatal dopamine. Irisin also substantially reduced the α-syn PFF-induced motor deficits as assessed behaviorally by the pole and grip strength test. Recombinant sustained irisin treatment of primary cortical neurons attenuated α-syn PFF toxicity by reducing the formation of phosphorylated serine 129 of α-syn and neuronal cell death. Tandem mass spectrometry and biochemical analysis revealed that irisin reduced pathologic α-syn by enhancing endolysosomal degradation of pathologic α-syn. Our findings highlight the potential for therapeutic disease modification of irisin in PD."
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