Good news! Looks very promising!
"A research paper published today [10/4/2023] ... presents a significant breakthrough in the area of skin regeneration and wound healing ...
The study ... shows the successful development of bioprinted skin that accelerate wound healing, support healthy extracellular matrix remodeling, and provide optimism for complete wound recovery. ..."
From the editor's summary and abstract:
"Editor’s summary
Full-thickness skin wounds are often treated with autologous skin grafting, but this option is limited by the volume of skin that can be harvested. Another treatment option consists of dermal skin substitutes, but results are frequently suboptimal. Here, Jorgensen and colleagues incorporated six human skin cell types into a multilayered skin construct through extrusion bioprinting. In vitro, this construct maintained a three-layer structure and matured appropriately. In mice, the construct accelerated wound healing and promoted neovascularization and extracellular matrix remodeling to reduce fibrosis and scar formation. In pigs, grafting with an autologous porcine bioprinted skin contruct led to increased epithelialization and reduced wound contraction, suggesting that bioprinted skin might be an alternative to treat human full-thickness wounds.
Abstract
Bioprinting is a promising alternative method to generate skin substitutes because it can replicate the structural organization of the skin into biomimetic layers in vitro. In this study, six primary human skin cell types were used to bioprint a trilayer skin construct consisting of epidermis, dermis, and hypodermis. Transplantation of the bioprinted skin with human cells onto full-thickness wounds of nu/nu mice promoted rapid vascularization and formation of epidermal rete ridges analogous to the native human epidermis, with a normal-looking extracellular matrix. Cell-specific staining confirmed the integration of the implanted cells into the regenerated skin. Using a similar approach, a 5 centimeter–by–5 centimeter bioprinted autologous porcine skin graft was transplanted onto full-thickness wounds in a porcine excisional wound model. The bioprinted skin graft improved epithelialization, reduced skin contraction, and supported normal collagen organization with reduced fibrosis. Differential gene expression demonstrated pro-remodeling protease activity in wounds transplanted with bioprinted autologous skin grafts. These results demonstrate that bioprinted skin can support skin regeneration to allow for nonfibrotic wound healing and suggest that the skin bioprinting technology may be applicable for human clinical use."
New wound healing research by Wake Forest Institute for Regenerative Medicine produces full thickness human bioprinted skin (secondary news source)
New Wound Healing Research By Wake Forest Institute for Regenerative Medicine Produces Full Thickness Human Bioprinted Skin (primary news source)
Researchers use cells and hydrogels as bioinks to 3D print human skin.
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