Blood-clotting protein may be SARS-CoV-2's hidden accomplice, helping it hide from antibodies and reach blood vessels

Amazing stuff!

Notice that the authors of this study could be considered to be "outsiders".

The lab leak hypothesis has never been disproven or refuted thanks to the secrecy and obstruction of the Communist Party of China! Was the SARS-Cov-2 just another naturally occurring coronavirus or something else?

Anthony Fauci made tremendous efforts to conceal and dismiss the lab leak hypothesis, because the Wuhan Institute of Virology (a dual research institute) did some research that was funded by the US government and US gain of function research was conducted there. How was this ever possible and approved!

"... The proposal offers a single mechanistic explanation for two features of COVID-19 that have long been treated as separate problems: the virus's ability to evade immunity and the vascular damage, microclotting and inflammation that characterize severe disease and long COVID. ...

SARS-CoV-2 is generally described as entering cells through the ACE2 receptor. But the spike protein carries clusters of positively charged lysine and arginine residues in its N-terminal domain (NTD) and receptor-binding domain (RBD).

In contrast, human fibrinogen is negatively charged at physiological pH. The authors argue this electrostatic attraction is more than incidental chemistry.

When fibrinogen binds the spike NTD, it can mask antigenic sites, providing a molecular shield against antibody detection. At the same time, the other end of the fibrinogen molecule, its gamma chain, engages endothelial receptors including the integrins αvβ3 and α5β1, platelet receptor GPIIb/IIIa and ICAM-1.

The result is a tether with the virus on one end and the blood vessel wall on the other. ..."

From the abstract:

"SARS-CoV-2 exploits multiple cellular entry routes. Beyond ACE2-mediated entry, we propose that the spike protein binds fibrinogen not only to facilitate immune evasion but also to position the receptor-binding domain for integrin-mediated uptake. This molecular bridge may enhance viral RNA delivery to endothelial cells. Targeting the spike protein–fibrinogen interface could open new therapeutic avenues for acute and post-COVID vascular disease."

Blood-clotting protein may be SARS-CoV-2's hidden accomplice, helping it hide from antibodies and reach blood vessels (This article was written by one of the authors of the research article below)

Fibrinogen as a Molecular Bridge Linking SARS-CoV-2 Immune Evasion and Endothelial Access? (no public access) "Fibrinogen as a Molecular Bridge Linking SARS-CoV-2 Immune Evasion and Endothelial Access?"

Visual abstract

COVID-19 can reawaken dormant viruses

Could this be more proof that a modified coronavirus (SARS-CoV-2) or perhaps a biological weapon was leaked from the Wuhan Institute of Virology in China. The Institute is believed to be a dual use research institute. What did Anthony Fauci know about this?

Or is this result just due to the super intensive research into the cause of Covid-19?

Or was this expected to happen due to the typically weakened immune system of an individual after Covid-19 infection?

Such reactivations of dormant viruses is definitely something to be aware of!

"As if an infection with SARS-CoV-2 wasn’t enough for a body to handle, the coronavirus reawakens a variety of other, dormant viruses in some people. A large new study delving into this phenomenon shows this virus reactivation is complex and the health impact murky, but it could worsen symptoms of COVID-19 and increase a person’s risk of Long Covid.

The study looked at tissues samples and medical reports from more than 1000 COVID-19 patients early in the pandemic. “Nearly half of people … had a virus that they were already carrying wake up,” said neuroimmunologist and co-author Esther Melamed. “This happens [even] in people whose immune systems are otherwise normal.”

The work has impressed some SARS-CoV-2 researchers. “The scale of the endeavor and the range of human viruses they’ve looked at” makes this the most comprehensive data set yet on viral reactivation in COVID-19 ..."

"Early in the COVID-19 pandemic, scientists noticed that a SARS-CoV-2 infection can “wake up” other, dormant viruses already present in the body.

A study out today in Nature extends those and subsequent observations, documenting viral reactivation for a cohort of more than 1000 patients hospitalized with COVID-19 before mid-2021. ...

The findings, which were partially described in a preprint in late 2024, include data on viruses previously overlooked in COVID-19 patients, he adds. ..."

From the abstract:

"Chronic viral infections are ubiquitous in humans, with individuals carrying multiple viruses that can reactivate during physiological stress, including severe illness.

Notably, SARS-CoV-2 infection has been shown to reactivate chronic viruses such as Epstein–Barr virus and cytomegalovirus, yet the full extent, temporal dynamics and immunological impact of viral reactivation in COVID-19 remain incompletely understood.

Here, leveraging multi-omic longitudinal data from 1,154 hospitalized patients with COVID-19 from the Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study, we reveal significant reactivation of Herpesviridae and Anelloviridae during acute COVID-19, with distinct temporal dynamics for different viruses, and demonstrate that reactivation correlates with disease severity, host immune effects and clinical outcomes.

Although our results do not establish causation between virus reactivation and clinical outcomes, we highlight the prevalence of chronic viral reactivation during acute COVID-19 and long COVID.

Our findings challenge the prevailing view that chronic viral reactivation is primarily a consequence of immunosuppression, demonstrating that reactivations occur frequently in immunocompetent individuals during severe illness and in association with increased systemic inflammation.

Additionally, we demonstrate persistence of viral reactivation in convalescence, and report an association of Anelloviridae with long COVID.

This study provides immune, transcriptomic and metabolomic signatures of viral reactivation that could inform future strategies to prognosticate and treat acute COVID-19 and long COVID."

ScienceAdviser

COVID-19 can wake up dormant viruses in the body, large study confirms "Virus reactivations by SARS-CoV-2 could worsen initial symptoms and increase risk of Long Covid"

Virus reactivation in acute and long COVID-19 (open access)

Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 (preprint from 2024, open access)

Fig. 1: The transcriptionally active human virome of the blood, upper airway and lungs in patients who were hospitalized for COVID-19.

Fig. 3: Antibody response, proteomics, and circulating cellular immunophenotyping validates chronic viral reactivation in COVID-19.

Days after the 46th President inauguration, FBI shielded Wuhan lab collaborator from investigation after China trip

Will the truth about the dual use Wuhan Institute of Virology, where the US conducted euphemistically called gain of function research finally come out?

Unfortunately, so far way too slow and drip by drip!

"46th 's presidency began and ended with the shielding of individuals linked to decades' worth of dangerous gain-of-function experiments.

[The 46th President] concluded his presidency by issuing former Director of the National Institute of Allergy and Infectious Diseases Anthony Fauci a blanket pardon, going back all the way to Jan. 1, 2014 — around the time the Obama administration supposedly halted funding for gain-of-function research that makes pathogens more deadly and/or more transmissible. ..."

Days after Biden inauguration, FBI shielded Wuhan lab collaborator from investigation after China trip | Blaze Media "The National Targeting Center wanted to subject Peter Daszak to a Tactical Terrorism Response Team exam. The Biden FBI had other ideas."

US Senator Rand Paul pushes for Anthony Fauci indictment for lying about gain of function research at the Wuhan Institute of Virology

What the hell took so long! Unfortunately, Anthony Fauci strategically retired just in time and is now over 85 years old!

I have blogged here as early as 2020 or so that something was very fishy about the US federal government funding so called gain of function research at that Institute of Virology in Wuhan, China, the possible source and lab leak of the SARS-CoV-2/Covid-19 virus. This Institute of Virology is also suspected to do dual use research.

"Sen. Rand Paul (R-Ky.) on Tuesday called for Anthony Fauci, former longtime director of the National Institute of Allergy and Infectious Diseases (NIAID), to be indicted for what the senator claimed was his lying under oath about gain-of-function research.

“6 days from now, on May 11th, the statute of limitations expires on the possibility of indicting Anthony Fauci for denying under oath that he funded gain-of-function research involving bat coronaviruses in Wuhan, the origin city of the pandemic,” Paul wrote on social media. ..."

Rand Paul pushes for Anthony Fauci indictment

Credits: The Flyover

Anthony Fauci

FDA halts new clinical trials seeking to send American cells to hostile labs like in China for genetic engineering

Good news! Long overdue!

What specimen were sent to the Institute of Virology in Wuhan (a dual use laboratory), China thanks to the crook Anthony Fauci?

FDA halts new clinical trials seeking to send American cells to hostile labs for genetic engineering | Just The News

Chinese neuroscientists’ work on early COVID-19 vaccine patent a smoking gun in probe of cover-up

It is several years overdue that the SARS-Cov-2/Covid-19 lab leak hypothesis is thoroughly investigated!

Other Western countries should have done so as well! Hopefully, they will join the US in this new investigation!

Was the release of the virus accidental or intentional? If it was intentional, then it was almost a perfect crime. Plausible deniability: The virus was released on its own territory first, thus victimizing the own population so it can spread to other parts of the world especially the US. Sounds crazy? Was the release of the virus meant to distract the world from something?

It was long ago reported that the Wuhan Institute of Virology is a dual use laboratory! Very suspicious!

That the US apparently funded and conducted so called gain of function research at the Wuhan Institute of Virology, which was then covered up by the crooked Anthony Fauci. Was that kind of research allowed in the US at the time (hint: doubtful)? This aspect also needs to be fully investigated.

The 46th President was too senile, demented and corrupt (how much bribe money did the Biden clan take from China) to investigate!

"One of the smoking guns in the ongoing Trump administration probe into the COVID-19 cover-up is evidence suggesting that the Chinese suspected the novel virus may have neurological symptoms just weeks after it was officially identified, despite the fact that coronaviruses, historically, primarily affect the respiratory and digestive systems. 

Specifically, two scientists listed as authors on the first Chinese patent for a COVID-19 vaccine—that remarkably came about a month after the virus crossed the border into the U.S.—are affiliated with a neuroscience institute in Beijing that works closely with the Chinese military.  ..."

Chinese neuroscientists’ work on early COVID-19 vaccine patent a smoking gun in probe of cover-up | Just The News "The unusual collaboration between Chinese vaccine researchers and neuroscientists raises questions about how early China knew about COVID-19’s neurological symptoms, which are unusual for these types of viruses."

Trump keeps promise by signing Executive Order banning federal funding for gain-of-function research in countries like China and Iran

Good news! Bravo! About time!

It was perhaps one of the greatest, mostly underreported scandals of the Covid-19 pandemic that the US government funded gain of function research at the Wuhan Institute of Virology, which is a also a bioweapons research institute. If I am not mistaken, this became known in 2020 and I blogged about it beginning in May 2021 (see e.g. here). The other huge and underreported scandal was the egregious, repeated abuse of the FISA court.

Then NIH Director Francis Collins and then Director of the National Institute of Allergy and Infectious Diseases (NIAID) Anthony Fauci (then age 80) were the main perpetrators of this scandal. Unfortunately, the first Trump Administration did not realize that! Trump should have fired or demoted these two charlatans/quacks! These two bad actors also undermined the lab leak hypothesis. Was this some kind of Faustian Bargain?

Was this e.g. an attempt to circumvent stricter regulations for and/or possible public outcry against this kind of research in the US?

"President Donald Trump on Monday kept a promise he made last year by signing an executive order that bans federal funding for gain-of-function research in countries like China and Iran, which is believed to be at the heart of the COVID-19 lab leak in Wuhan. ..."

"... This Executive Order:

• Ends any present and all future Federal funding of dangerous gain-of-function research in countries of concern like China and Iran and in foreign nations deemed to have insufficient research oversight. 

..."

Trump keeps promise by signing EO banning federal funding for gain-of-function research | Just The News ""For decades, policies overseeing gain-of-function research on pathogens, toxins, and potential pathogens have lacked adequate enforcement, transparency, and top-down oversight," the White House said in a fact sheet. "Researchers have not acknowledged the legitimate potential for societal harms that this kind of research poses.""

Fact Sheet: President Donald J. Trump Achieves Improved Safety and Security of Biological Research

Elon Musk Says USAID Funded BIOWEAPONS Research In Wuhan--Emily Kopp

Early in 2020 it was already reported that the US federal government funded dubious virus research at the Wuhan Institute of Virology and that this Institute was a dual use research facility.

Perhaps, SARS-CoV-2/Covid-2 was not just a lab leak, but a live test of a bioweapon that spared children and was very infectious, but not very deadly.

Thanks to the senile, demented and CORRUPT 46th President this was never really investigated, because the Chinese knew too much about the corrupt Biden clan.

SARS-CoV-2: Nicht nur "zivile Forschung", auch die Armee war in Wuhan dabei. Wirklich!

Das ist nichts neues! Das ist seit etwa mindestens 3 Jahren bekannt. Darüber habe ich hier auch mehrmals gebloggt!

Das Wuhan Institut der Virologie ist ein sog. dual use Institut. Es wurde dort zivile als auch militärische Forschung betrieben. Der Virus war viel zu ansteckend als es für einen natürlichen Virus anzunehmen ist.

Warum die USA dort u.a. gain of function Forschung finanziert hat ist eines der vielen Merkwürdigkeiten der Covid-19 Pandemie! Dr. Anthony Fauci (Dr. Faust) hat gelogen bis die Balken sich gebogen haben.

Die Frage ist nur war es ein Unfall oder absichtliche Freisetzung des Virus!

"Ein neuer Bericht aus den Vereinigten Staaten legt nahe, dass SARS-CoV-2 mit sehr hoher Wahrscheinlichkeit in einem Labor entstanden ist und durch einen Unfall freigesetzt wurde. Der prominenteste Vertreter dieser These war und ist Professor Roland Wiesendanger, tätig an der Universität Hamburg im Lehrstuhl für Physik. Schon zu Beginn der Pandemie kam er zu dem Schluss, dass es nicht natürlichen Ursprungs sein kann. ..."

SARS-CoV-2: Nicht nur "zivile Forschung", auch die Armee war in Wuhan dabei "Ein Bericht aus den USA will nun nachweisen, dass das Corona-Virus aus einem Labor in Wuhan entkommen ist und vorher durch Gain-of-function-Forschung erst gefährlich gemacht wurde. Auch in Deutschland findet solche Forschung statt, erklärt Roland Wiesendanger. Eine Pandemie wurde von Spitzen-Virologen billigend in Kauf genommen."

Biden probe into COVID origins censored reports the virus was likely genetically engineered

Will the truth about the origin of SARS-CoV-2/Covid-19 finally come out? How about a lab leak! As I have blogged here frequently, it was known latest by mid-2020 that this virus was extremely infectious right from the very beginning and the first cases were reported coming from the Wuhan Institute of Virology!

Why did the U.S. government finance and get involved with viral research at this WIV? Was this research legal in the U.S.? So why did Anthony Fauci and Francis Collins suppress the lab leak hypothesis in favor of zoonotic origin?

Did the Communist Party of China try to influence the U.S. presidential election of November 2020? Or was the lab leak not accidental?

U.S. National Institutes of Health took royalties from Wuhan lab collaborator, alleged front for Russian bioweapons

Incredible! Is the truth finally coming out why the lab leak hypothesis was so intensively suppressed by the U.S. government, Anthony Fauci, and Francis Collins?

Unfortunately, this does not look very good on former President Trump either! Either he failed to recognize the issues related to the Wuhan Institute of Virology or he choose to gloss over it.

As I have blogged here multiple times since 2020, the fact that the U.S. government financed and supported dangerous virus research at this lab, which was likely prohibited in the U.S. is a very disturbing event! Further, it was reported multiple times that this lab was dual use (civilian and military research).

"The National Institutes of Health and its scientists received royalties from Chinese Communist Party-controlled pharmaceutical companies, including one that collaborated with a suspected source of the COVID-19 pandemic, and a Russian vaccine maker that reportedly may have served as a front for Soviet bioweapons research, according to newly disclosed records. ...

NIH fought to shield the identities of the entities that paid to license its taxpayer-funded inventions from the agency and individual scientists, including then-Director Francis Collins and then-National Institute of Allergy and Infectious Diseases Director Anthony Fauci, who together received 58 payments from seven companies. ..."

NIH took royalties from Wuhan lab collaborator, alleged front for Russian bioweapons: records | Just The News

U.S. Senator Rand Paul announces DOJ criminal referral for Anthony Fauci over claims about gain-of-function research

What the heck took so long!!!! The involvement of the U.S. government in financing and supporting controversial pathogen research at the Wuhan Institute of Virology (a facility, where possibly civilian and military research was conducted side by side) was already well known by around mid 2020 or latest by end of 2020. I have extensively blogged here about that since 2020 (e.g. label coronavirus)!

Unfortunately, the current, ultra partisan U.S. Attorney General Merrick Garland needs to be impeached first!!!!

This U.S. government sponsored research at that Chinese lab was most likely in circumvention of existing U.S. regulations regarding such research!

"Sen. Rand Paul, a Kentucky Republican, announced that he formally sent a criminal referral to the Justice Department regarding Dr. Anthony Fauci, the former National Institute of Allergy and Infectious Diseases director.

Paul cited an email from February 2020 in which Fauci wrote that scientists discussed whether COVID-19 was produced through genetic engineering at the Wuhan Institute of Virology.

"This suspicion was heightened by the fact that scientists in Wuhan University are known to have been working on gain-of-function experiments to determine the molecular mechanisms associated with bat viruses adapting to human infection, and the outbreak originated in Wuhan," he wrote in the email, which was published by RealClearNews reporter Philip Wegmann on Saturday.

"This directly contradicts everything he said in committee hearing to me, denying absolutely that they funded any gain-of-function, and it’s absolutely a lie. That’s why I sent an official criminal referral to the DOJ," Paul wrote on Twitter in response to Wegmann's tweet."

Rand Paul announces DOJ criminal referral for Fauci over claims about gain-of-function research | Just The News

Biden administration suspends funding for Wuhan lab. Really!

It took the U.S. government only 3.5 years to do this! We are so blessed with so much wisdom (pardon my facetious remark)!

"The Biden administration has suspended funding for the Wuhan Institute of Virology following a monthslong review that determined that the Chinese research institute “is not compliant with federal regulations and is not presently responsible,” according to a memo from the Department of Health and Human Services.

HHS, which conducted the review, also proposed barring the Wuhan Institute from doing business with the federal government going forward, according to the memo, which is dated to Monday and was first reported by Bloomberg.

The lab has not received any federal funding from the US National Institutes of Health since July 2020 [are we to believe this?], according to an HHS spokesperson. ..."

Biden administration suspends funding for Wuhan lab | CNN Politics

U.S. EcoHealth Alliance subcontractor/researcher among COVID-19 'patients zero' at Wuhan lab: Report

That seems to be a bombshell!

The immediate very high and very effective human infectiousness of the SARS-CoV-2 was from the very beginning (early 2020) a telltale sign that it may have originated in a lab and not in nature! I have said this many times since early 2020.

Anthony Fauci needs to be investigated and possibly prosecuted! Then President Trump made a huge mistake not to fire or at least demote this charlatan and clown!

The involvement of the U.S. with  the Wuhan Institute of Virology prior to the global COVID-19 pandemic is an enormous scandal on which I have blogged here multiple times! This kind of euphemistically called gain of function research would not have been legally possible in the U.S. so it was carried out in China! Incredible!

"A damning new report indicates Peter Daszak's EcoHealth Alliance, the National Institute of Allergy and Infectious Diseases under Anthony Fauci, and the Chinese military-co-opted Wuhan Institute of Virology all have their fingerprints on research that may have ultimately resulted in the deaths of over 1.1 million Americans and well over 6.9 million worldwide. ...
reveal the NIAID and United States Agency for International Development funded an EcoHealth Alliance subcontractor's work on coronaviruses to the tune of $41 million. ...
That subcontractor, listed as an investigator on the grants, was Ben Hu, whom TheBlaze previously noted was the WIV's lead on gain-of-function research on SARS-like coronaviruses and among the "patients zero" — having been one of the three lab researchers first infected with COVID-19 in November 2019. ..."

EcoHealth Alliance subcontractor among COVID-19 'patients zero' at Wuhan lab: Report - TheBlaze

China's Covid Secret: Wuhan lab's deadly bioweapon experiment

Very recommendable! Was there already a 2016 outbreak of coronavirus epidemic in Hubei province (capital Wuhan) similar to Covid-19?

I have blogged here multiple times about the lab leak hypothesis and the involvement of the very strange U.S. government involvement (e.g. Anthony Fauci) with the Wuhan Institute of Virology (WIV).

It was reported several times that the WIV may have acted as a dual use research facility, conducting both civilian and military research.

US National Institutes of Health reinstates grant to EcoHealth Alliance for more controversial coronavirus research in China

Why is any of this research conducted in a totalitarian dictatorship and at a research institute that is also possibly involved in the development of biological weapons?

The lab leak hypothesis is still the best explanation!

There is also a strong suspicion that this research was done in circumvention of stricter U.S. regulations!!!

This is insane and irresponsible!

"The US National Institutes of Health (NIH) has reinstated a grant to a highly scrutinized research organization that studies bat coronaviruses — but the agency has placed several stipulations on the scope of the research and on the organization’s accounting practices.

The move caps a years-long saga that has thrust the EcoHealth Alliance, a small non-profit organization in New York City, into the political fray for its collaborations with the Wuhan Institute of Virology (WIV) in China. In April 2020, after then-US-president Donald Trump hinted that SARS-CoV-2 originated in a WIV laboratory, the NIH terminated EcoHealth’s grant. ...
Researchers who spoke to Nature applaud the renewal [???], adding that this type of research is essential to avert the next pandemic. ..."

NIH reinstates grant for controversial coronavirus research EcoHealth Alliance lost funding during the Trump administration, but can now proceed with its research — under extensive restrictions.

National Institutes of Health renews grant to EcoHealth Alliance to fund more virus experiments at Wuhan Institute of Virology. Really!

What!!! This is insane! It is very dubious for any Western government to fund research at such Communist Party of China run research institutes!

The lab leak hypothesis (accidental or intentional?) is still the best explanation! Do we know whether this Institute also has carried out biological weapons research? 

The federal government has financed so called "gain of function" research before Covid-19 at this Institute probably in circumvention of stricter  federal regulations!

NIH renews grant to organization that funded coronavirus experiments in Wuhan | Just The News The organization confirmed that it had "revised" the aims of its experiments amid "ongoing concerns by removing all on-the-ground work in China and all recombinant virus culture or infection experiments."

EcoHealth Alliance Receives NIH Renewal Grant for Collaborative Research to Understand the Risk of Bat Coronavirus Spillover Emergence

What is a raccoon dog? The animal that may have started the COVID pandemic. Really!

Just another one of already far too many attempts of diversion, deflection, or cover up of the lab leak hypothesis!

Not to mention that the U.S. government financed gain of function research at the dubious Wuhan Institute of Virology in circumvention of stricter U.S. regulations regarding this kind of research! Right Messrs. Anthony Fauci and Francis Collins!

What is a raccoon dog? The animal that may have started the COVID pandemic

Did the US help China cover-up Covid-19 outbreak? Yes, it appears so

Very recommendable! I have blogged here multiple times over the past two years about the lab leak hypothesis (click tag below).

Facts are that the U.S. financed gain of function research at the Wuhan Institute of Virology, that it was know that the safety features of this lab were likely inadequate ...

Scientist who worked closely with the Wuhan lab says COVID was genetically engineered and leaked

The lab leak hypothesis is very plausible!  I have blogged here several times about it (see tag below). E.g. the supposedly zoonotic virus was immediately extremely contagious to humans.

80 year old Anthony Fauci promoted gain of function research at the Wuhan Institute of virology most likely in circumvention of stricter U.S. regulations. Because of the U.S. government involvement with this Institute, a cover up became necessary!

"Former vice president of EcoHealth Alliance Dr. Andrew Huff says that he worked closely with the Wuhan Institute of Virology lab in China and he knows that COVID was genetically engineered and leaked. 

Huff says that COVID was "one of the greatest cover-ups in history" and the "biggest US intelligence failure since 9/11."

Whistleblower Dr. Huff wrote a book titled The Truth About Wuhan in which he claims that the COVID-19 pandemic happened because of the U.S. government's funding of genetic engineering of coronaviruses in China. 

"EcoHealth Alliance and foreign laboratories did not have the adequate control measures in place for ensuring proper biosafety, biosecurity, and risk management, ultimately resulting in the lab leak at the Wuhan Institute of Virology," he wrote in his book. An exclusive pre-release was given to The Sun Online. 

Dr. Huff wrote in his book that China knew from day one that this was a "genetically engineered agent." Huff, an epidemiologist and army veteran who worked for EcoHealth Alliance from 2014 to 2016, said it was China's gain-of-function experiments — and shoddy biosecurity — that led to the lab leak at the U.S.-funded lab.  ..."

Scientist who worked closely with the Wuhan lab says COVID was genetically engineered and leaked | Just The News Dr. Huff says that COVID was 'one of the greatest cover-ups in history' and the 'biggest US intelligence failure since 9/11.'