Good news! This could be a game changer!
"Late last month [June 2026], the National Institutes of Health (NIH) announced an expansion of the All of Us database. The United States created the All of Us research program to capture the diversity of the American population by building a comprehensive database to help solve the country’s health challenges through research.
The latest update expands the program’s database, which now includes health data from over 747,000 participants and adds, for the first time, multiomics information such as proteomics and RNA sequencing (RNAseq) data. ...
Over the last seven years, the All of Us database has expanded significantly. The latest update brings the number of EHRs close to 482,000 and makes health information from over 747,000 participants available to researchers. These data, in turn, provide an in-depth look at participants’ genomic information, including more than 1.3 billion genetic variants, 553,000 genotyping arrays, and 96,000 structural variant records ...
Additionally, the new dataset now encompasses 600,000 physical measurements and survey responses from 747,000 participants, providing social, environmental, and behavioral information. ..."
"Today [6/30/2026], the National Institutes of Health's All of Us Research Program made history, unveiling the world's largest integrated dataset that combines unparalleled genomic depth with real-world clinical and wearable data. More than 747,000 participants across all 50 states and territories have shared data, enabling the linkage of nearly 482,000 electronic health records connected to 535,000 whole genome sequences. ...
This release moves All of Us beyond sequencing and into the multiomics era, providing researchers with unmatched statistical power.
- Short-Read Whole Genome Sequencing: The short-read Whole Genome Sequencing has grown to include more than 535,000 participants.
- Overlapping Multiomics Cohort: Over 8,000 participants of diverse genetic ancestry now have fully overlapping multiomics data across three advanced modalities: long-read sequences (>14,000 total available), proteomics (nearly 10,000 total), and RNA-seq (nearly 9,000 total).
- Over 1.3 Billion Total Genetic Variants: Providing unparalleled resolution to map rare and common diseases.
- Advanced Analytical Capabilities: New built-in tools allow for efficient, standardized analyses of relatedness, phasing, pharmacogenomics, and newly debuted HLA and mtDNA analysis.
- Targeted Callsets: Includes deep-dives into the exome, ClinVar, AC/AF thresholds, and CMGR to drastically improve variant-calling accuracy.
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Transformative Real-World Data: EHR, Wearables & Environment
All of Us dramatically expands the real-world data available to researchers. Clinical utility has scaled massively, bridging the gap between genetic codes and real-world diagnoses.
- 22% Growth in Electronic Health Record (EHR) Data: Strategic expansion of EHR data sources for growth in phenotypic data offerings with participant-mediated EHR data (58K participants) and HIE EHR data from CLAD (15K participants). Linked EHR have grown to nearly 482,000, now connected to 535,000 WGS samples.
- First-Ever Clinical Notes Release – an unprecedented depth in phenotyping: Registered researchers now have secure access to unstructured clinical text, with 96 million NLP-derived concept codes extracted from 9.5 million clinical notes across more than 99,000 participants using the CLAMP tool, all mapped to the OMOP standard vocabulary for seamless cross-referencing with genomic data.
- World's Largest Accessible Fitbit Dataset: Active tracking data is now available for 68,000 participants, with Apple HealthKit integration coming soon for an initial 20,000.
- New Sleep Data Tables: Three new Fitbit sleep tables add granular longitudinal insights, including daily sleep stage summaries (REM, light, deep, wake) for 62,000 participants, derived sleep log metrics, and micro-indicators of sleep fragmentation.
- Geospatial & Environmental Data: An upcoming release will integrate residential and geographic data linkages, enabling researchers to study air quality, neighborhood resources, and social determinants of health alongside genetics.
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To date, nearly 23,000 registered researchers at institutions across every state have used the All of Us Researcher Workbench, producing over 1,400 peer-reviewed publications.
This secure cloud-accessible platform democratizes science, giving a researcher at a small community college or a high school student the exact same computational power and data access as a Nobel laureate at a coastal institution. That access has already led to:
- A first-of-its-kind genetic test predicting inherited risk across eight cardiovascular conditions.
- A low-cost prostate cancer risk model now in clinical trial with 5,000 Veterans.
- Researchers identifying existing medications and novel genetic changes that may help prevent Alzheimer's disease..
- Data showing that 8,000 to 9,000 daily steps are a meaningful protective threshold across multiple chronic conditions.
..."
The NIH’s All of Us Database Expands into Multiomics | The Scientist "With RNAseq and proteomics data from thousands of people, the database provides scientists with diverse precision health data on almost 750,000 people to power research."
